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COMPLEMENT C5A
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DeCS
Descriptor
English
:
Complement C5a
Descriptor
Spanish
:
complemento C5a
Descriptor
Portuguese
:
Complemento C5a
Synonyms
English
:
C5a Complement
C5a, Complement
Complement 5a
Complement Component 5a
Complement, C5a
Component 5a, Complement
Tree Number:
D12.776.124.486.274.024.270
D12.776.124.486.274.450.250
Definition
English
:
The minor fragment formed when C5 convertase cleaves C5 into C5a and
COMPLEMENT C5B
. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal
ARGININE
that is crucial for its spasmogenic activity. Of all the complement-derived
anaphylatoxins
, C5a is the most potent in mediating immediate
hypersensitivity
(
HYPERSENSITIVITY
, IMMEDIATE), smooth
MUSCLE CONTRACTION
;
HISTAMINE RELEASE
; and migration of
LEUKOCYTES
to site of
INFLAMMATION.
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1990)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
24580
Unique Identifier:
D015936
Occurrence in VHL
:
Similar:
DeCS